4-Cyclopentylphenol → (2R)-7-(3-(2-Chloro-4-cyclopentylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

HRID 51091

Reaktionsgleichung

Reaktionsgleichung von HRID 51091
C1(C2C=CC(O)=CC=2)CCCC1.[Cl:13][C:14]1[CH:38]=[C:37]([CH:39]2C[CH2:43][CH2:42][CH2:41][CH2:40]2)[CH:36]=[CH:35][C:15]=1[O:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:30]=[C:29]2[C:24]([CH2:25][CH2:26][C@:27]([CH3:34])([C:31]([OH:33])=[O:32])[O:28]2)=[CH:23][CH:22]=1>>[Cl:13][C:14]1[CH:38]=[C:37]([CH:39]2[CH2:40][CH2:41][CH2:42][CH2:43]2)[CH:36]=[CH:35][C:15]=1[O:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:30]=[C:29]2[C:24]([CH2:25][CH2:26][C@:27]([CH3:34])([C:31]([OH:33])=[O:32])[O:28]2)=[CH:23][CH:22]=1

Komponenten

3

Edukt 2

HCID 152024-CyclopentylphenolHCID 10182946(2R)-7-(3-(2-Chloro-4-cyclohexylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

Produkt 1

HCID 10114442(2R)-7-(3-(2-Chloro-4-cyclopentylphenoxy)propoxy)-2-methylchromane-2-carboxylic Acid

Versuchsvorschrift

The title compound was prepared following the procedures described in Example 5, Steps B-E employing 4-cyclopentylphenol instead of 4-(2,2,2-trifluoroethoxy)phenol, and (2R)-methyl 2-methyl-7-hydroxychromane-2-carboxylate (Example 23, Step A) instead of ethyl 7-hydroxychromane-2-carboxylate.

Quellen und Nachweise

ORD-Eintrag
ord-05b99a15b42745d292a0242b5b45f933
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713508B2

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