HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(+-)-3-Quinuclidinol → 3-(4-Methoxybenzylthio)quinuclidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (+-)-3-Quinuclidinol | HCID 15381 | — |
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | 4-Methoxy-alpha-toluenethiol | HCID 80407 | — |
| Edukt | 1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate | HCID 416494 | — |
| Produkt | 3-(4-Methoxybenzylthio)quinuclidine | HCID 19797265 | — |
Reaktionsschritte
The procedure described in Preparation 6-(2) was repeated, but using 3.7 g of 3-methanesulfonyloxyquinuclidine (prepared by the methanesulfonylation of 3-quinuclidinol), 3.0 ml of 4-methoxybenzyl mercaptan and 0.942 g of sodium hydride (as a 55% w/w suspension in mineral oil), to afford 1.74 g of the title compound as an oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05242914 |
| Quelldatensatz | uspto-grants-1993_09 |
| ORD ID | ord-b1ecc63b5cfd4eac90d16e7b577321a5 |
| Quellennotiz | uspto-grants-1993_09 |