Hydrochloric Acid → HCID 67292072, Verbindung

Reaktionsgleichung

FC(F)(F)[C:3]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:11][CH:12]=2)[N:7]([CH3:18])[CH:6]=1)=[O:4].[OH-:21].[Na+].Cl>>[CH3:18][N:7]1[C:8]2[C:13](=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:5]([C:3]([OH:4])=[O:21])=[CH:6]1

Komponenten

Edukt 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 86664378HCID 86664378, Verbindung

Produkt 1

HCID 67292072HCID 67292072, VerbindungAusbeute 67 %

Versuchsvorschrift

A mixture of 2,2,2-trifluoro-1-(1-methyl-6-(trifluoromethyl)-1H-indol-3-yl)ethanone (195 mg, 0.66 mmol) and 20% aqueous sodium hydroxide solution (5 mL) was refluxed with stirring for 10 hours. After cooling to room temperature, the mixture was poured into 1 M hydrochloric acid, and the aqueous phase was extracted with ethyl acetate (twice). The combined organic layers were dried over magnesium sulfate and concentrated in vacuo. The residual solid was washed with 2-propanol to give 107 mg (67% yield) of the title compound as a pale orange solid: