Sodium Hydroxide → 5-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid

HRID 511842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 511842
[F:1][C:2]([F:17])([F:16])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([O:13]CC)=[O:12])=[N:9][CH:10]=1.[OH-].[Na+]>CO>[F:17][C:2]([F:1])([F:16])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 67291773Ethyl 5-(2,2,2-trifluoroethoxy)picolinate

Produkt 1

HCID 574758545-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acidAusbeute 53,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 5-(2,2,2-trifluoroethoxy)picolinate (253 mg, 1.0 mmol) and 2 mol/L aqueous sodium hydroxide solution (1.0 mL, 2.0 mmol) in methanol (5 mL) was stirred at room temperature for 4 h. Then, methanol was removed in vacuo. To the residue were added water (2 mL) and 2 mol/L hydrochloric acid (pH˜4). The formed precipitate was collected by filtration to give 118 mg (52% yield) of the title compound as a gray solid:

Aufarbeitung

  1. customThen, methanol was removed in vacuo
  2. additionTo the residue were added water (2 mL) and 2 mol/L hydrochloric acid (pH˜4)
  3. filtrationThe formed precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-7118358fcc5d4b8db297da7164d6e77f
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09101616B2

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