Chloride → 2-(5-Chloropyridin-3-yl)acetonitrile

HRID 512141

Reaktionsgleichung

Reaktionsgleichung von HRID 512141
[Cl-:1].S(Cl)(Cl)=O.[C-]#N.[K+].FC(F)(F)[C:11]1[N:16]=[CH:15][C:14]([CH2:17][C:18]#[N:19])=[CH:13][CH:12]=1>>[Cl:1][C:12]1[CH:13]=[C:14]([CH2:17][C:18]#[N:19])[CH:15]=[N:16][CH:11]=1

Komponenten

5

Edukt 4

HCID 312Chloride2×HCID 9032Potassium CyanideHCID 24386Thionyl ChlorideHCID 508511273-Pyridineacetonitrile, 6-(trifluoromethyl)-

Produkt 1

HCID 552659022-(5-Chloropyridin-3-yl)acetonitrile

Versuchsvorschrift

Conversion of the hydroxyl group to the chloride using thionyl chloride, followed by the displacement of the chloride by potassium cyanide was performed using the same procedures described for (6-trifluoromethyl-pyridin-3-yl)-acetonitrile. 1H NMR (400 MHz, CDCl3) δ ppm 8.55 (d, J=2.0 Hz, 1 H), 8.50 (d, J=1.1 Hz, 1 H), 7.73 (s, 1 H), 4.58 (s, 2 H). MS m/z 153.0

Quellen und Nachweise

ORD-Eintrag
ord-7629e815c06247809eb898374acc3379
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102591B2

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