Ammonia → (2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

HRID 512208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 512208
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1.N>CO.[Ni]>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][O:9]2)=[CH:4][N:3]=1

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 867162372-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile

Produkt 1

HCID 86716238(2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

2-(2-Methylpyrimidin-5-yl)tetrahydrofuran-2-carbonitrile (18 mg, 0.095 mmol) was dissolved in MeOH(5 ml) and 7M NH3 in MeOH (1 ml). Argon was bubbled through the solution. Raney Nickel (6 mg, 0.1 mmol) was added and the flask was fitted with a H2-balloon and stirred at room temperature for 1½ hour. Reaction was filtred through a plug of celite and concentrated in vacuo. Used for next step without further purification. LC-MS (m/z) 194.0 (MH+), tR (minutes, Method D)=0.17.

Aufarbeitung

  1. customArgon was bubbled through the solution
  2. customthe flask was fitted with a H2-balloon
  3. customReaction
  4. concentrationconcentrated in vacuo
  5. customUsed for next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-6221c7e565f74f5e8f6930fb652ed982
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102591B2

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