2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

Beteiligte Stoffe

Reaktionsschritte

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

Herkunft & Nachweise