4-(2,3-Dimethoxybenzoyl)pyridine → (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

HRID 51269

Reaktionsgleichung

Reaktionsgleichung von HRID 51269
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:4]=1[C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=[O:6]>CO.[Rh]>[OH:6][CH:5]([CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[C:4]1[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH3:18])[C:3]=1[O:2][CH3:1]

Komponenten

4

Edukt 1

HCID 4285494-(2,3-Dimethoxybenzoyl)pyridine

Produkt 1

HCID 10890362(2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23948RhodiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(2,3-Dimethoxybenzoyl)pyridine (12) (10.09 g, 42 mmol) was dissolved in 100 mL of methanol and hydrogenated using a 5% rhodium on carbon catalyst. At the conclusion of the reaction, the catalyst was removed by filtration. The filtrate weighed 113.90 g. The reactor and catalyst cake were washed with methanol. The combined washes weighed 165.26 g.

Aufarbeitung

  1. customAt the conclusion of the reaction
  2. customthe catalyst was removed by filtration
  3. washThe reactor and catalyst cake were washed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-6b10edf3e7124686b34939f0cde5bae9
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713627B2

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