Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| Edukt | Oxalyl chloride | HCID 65578 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 4-Fluorophenylacetyl chloride | HCID 3744988 | — |
Reaktionsschritte
Into a suitable agitated reactor is charged 4-fluorophenylacetic acid (79.4 kg, 515 mol), N,N-dimethylformamide (0.5 kg, 6.8 mol), and toluene (318 kg). Oxalyl chloride (68.3 kg, 538 mol) is added at a rate as to maintain the temperature below 35° C. The solution is stirred for at least 7 hours at about 25° C., typically affording a 22.1 wt % solution of 4-fluorophenylacetyl chloride.1
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06713627B2 |
|---|
| Quelldatensatz | uspto-grants-2004_03 |
|---|
| ORD ID | ord-8fc5d48602a040af9095623c7c408705 |
|---|
| Quellennotiz | uspto-grants-2004_03 |
|---|
