Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Dimethylformamide | HCID 6228 | — |
| Edukt | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| Edukt | Oxalyl chloride | HCID 65578 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 4-Fluorophenylacetyl chloride | HCID 3744988 | 99% |
Reaktionsschritte
Into a suitable reactor is charged 4-fluorophenylacetic acid (122.5 kg, 795 mol), N,N-dimethylformamide (0.37 kg, 5.1 mol), and toluene (490 kg). Oxalyl chloride (105.2 kg, 829 mol) is added at a rate to maintain the temperature at about 35° C. The solution is stirred for at least 7 hours at about 25° C., typically affording a solution of about 22.1 wt % 4-fluorophenylacetyl chloride (99% yield as determined by HPLC assay).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06713627B2 |
|---|
| Quelldatensatz | uspto-grants-2004_03 |
|---|
| ORD ID | ord-627f2db91fef4c5b8d7b94a1450d4732 |
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| Quellennotiz | uspto-grants-2004_03 |
|---|
