Dimethylformamide → 2-Chloro-3-(trifluoromethyl)benzoyl chloride

Beteiligte Stoffe

Reaktionsschritte

To a suspension of 2-chloro-3-(trifluoromethyl)benzoic acid (15 g, 67 mmol) and catalytic DMF (0.06 mL, 0.67 mmol) in DCM (150 mL) was added oxalyl chloride (6.8 mL, 80 mmol) dropwise. The reaction was let stir (vigorous bubbling) for 4 h and concentrated to an oily solid which became solid after overnight drying on high vacuum.

Herkunft & Nachweise