HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 513295Erstellt: 25. Oktober 2026
Water → 6-Chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide
https://huagongshe.com/reaction/513295
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 4,6-Dichloronicotinamide | HCID 600044 | — |
| Edukt | (3-(Pyridin-2-yl)phenyl)methanamine | HCID 59151546 | — |
| Lösungsmittel | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Produkt | 6-Chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide | HCID 86664551 | 43,5% |
Reaktionsschritte
To a solution of 4,6-dichloronicotinamide (73 mg, 0.38 mmol) in NMP (0.75 mL) was added (3-(pyridine-2-yl)phenyl)methanamine (77 mg, 0.42 mmol) and DIPEA (0.22 mL, 1.33 mmol). After stirring at 80° C. for 15 h, the mixture was added water, the resulting precipitate was collected by filtration to give 6-chloro-4-(3-(pyridine-2-yl)benzylamino)nicotinamide (56 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09102625B2 |
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| Quelldatensatz | uspto-grants-2015_08 |
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| ORD ID | ord-e91be3ccec2d491cb3757dd53ea73e35 |
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| Quellennotiz | uspto-grants-2015_08 |
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