HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Stannous Chloride → 8-Quinolinamine, 5-(trifluoromethyl)-
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Stannous Chloride | HCID 24479 | — |
| Edukt | 8-Nitro-5-(trifluoromethyl)quinoline | HCID 68183100 | — |
| Katalysator | Hydrochloric Acid | HCID 313 | — |
| Produkt | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | 85,5% |
Reaktionsschritte
In a similar fashion using route 1 general procedure 4, 8-nitro-5-(trifluoromethyl)quinoline (Intermediate 33) (820 mg, 3.39 mmol), tin (II) chloride (1.93 g, 10.2 mmol) and 6 N HCl (10 drops) gave the title compound (615 mg, 85%) which was used in the next step without purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-975e25dcd1ed40b6afd70c4f19df1dfd |
| Quellennotiz | uspto-grants-2015_08 |