5-Chloroquinolin-8-amine → N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide

HRID 513511Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 513511
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[N+:13]([C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:17]=1[S:26](Cl)(=[O:28])=[O:27])([O-:15])=[O:14]>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([NH:12][S:26]([C:17]2[CH:18]=[CH:19][C:20]([C:22]([F:24])([F:25])[F:23])=[CH:21][C:16]=2[N+:13]([O-:15])=[O:14])(=[O:27])=[O:28])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Komponenten

3

Edukt 2

HCID 2248605-Chloroquinolin-8-amine2×HCID 27757802-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

Produkt 1

HCID 68182997N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamideAusbeute 99,3 %

Versuchsvorschrift

In a similar fashion using route 14 general procedure 26, 5-chloroquinolin-8-amine (Intermediate 27) (50 mg, 0.28 mmol), 2-nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride (162 mg, 0.56 mmol) gave the title compound (120 mg, 50%) after purification by column chromatography with DCM as the eluent.

Quellen und Nachweise

ORD-Eintrag
ord-2ab982025e0942ceae1bf14906624934
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102688B2

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