Trifluoromethanesulfonate → HCID 60164095, Verbindung

HRID 513647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 513647
[C:1]1([NH:7][CH2:8][C:9]2[C:18]([NH2:19])=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1([S:25](N2C=C[N+](C)=C2)(=[O:27])=[O:26])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[C:1]1([N:7]2[S:25](=[O:27])(=[O:26])[NH:19][C:18]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][N:16]=4)[CH:11]=[CH:10][C:9]=3[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150, VerbindungHCID 681831547-Phenylaminomethyl-quinolin-8-ylamine2×

Produkt 1

HCID 60164095HCID 60164095, VerbindungAusbeute 4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A solution of 7-phenylaminomethyl-quinolin-8-ylamine (Intermediate 206) (350 mg, 1.4 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (762 mg, 2.1 mmol) in MeCN (10 ml) was stirred at 0° C. then allowed to warm to room temperature overnight. The reaction mixture was concentrated in vacuo and the crude residue was purified by preparative HPLC (basic conditions) to give the title compound (18 mg, 4%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude residue was purified by preparative HPLC (basic conditions)

Quellen und Nachweise

ORD-Eintrag
ord-e3896450a3ab4be08919dc43894bb617
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102688B2

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