Trifluoromethanesulfonate → HCID 60164096, Verbindung

HRID 513652Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 513652
[NH2:1][CH2:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.N1([S:19](N2C=C[N+](C)=C2)(=[O:21])=[O:20])C=CN=C1.FC(F)(F)S([O-])(=O)=O>CC#N>[CH2:2]1[C:3]2[CH:4]=[CH:5][C:6]3[C:11](=[N:10][CH:9]=[CH:8][CH:7]=3)[C:12]=2[NH:13][S:19](=[O:21])(=[O:20])[NH:1]1

Komponenten

5

Edukt 3

HCID 2758875TrifluoromethanesulfonateHCID 11728150HCID 11728150, VerbindungHCID 68183296HCID 68183296, Verbindung2×

Produkt 1

HCID 60164096HCID 60164096, VerbindungAusbeute 6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

7-Aminomethyl-quinolin-8-amine (Intermediate 211) (50 mg, 0.29 mmol) and 1-(1H-imidazole-1-sulfonyl)-3-methyl-1H-imidazol-3-ium; trifluoromethanesulfonate (157 mg, 0.43 mmol) in MeCN (5 ml) was stirred at room temperature for 18 h. The reaction mixture was concentrated in vacuo. The crude residue was purified by preparative HPLC (basic conditions) to give the title compound (4.5 mg, 6%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude residue was purified by preparative HPLC (basic conditions)

Quellen und Nachweise

ORD-Eintrag
ord-a81072e81dc74f008a55d7fc33eee212
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102688B2

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