(Z)-2-Hydroxy Doxepin → (E)-2-Hydroxy Doxepin

HRID 514283

Reaktionsgleichung

Reaktionsgleichung von HRID 514283
[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]/[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1>Cl.CO>[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]\[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1

Komponenten

4

Edukt 1

HCID 67319009(Z)-2-Hydroxy Doxepin

Produkt 1

HCID 59023617(E)-2-Hydroxy Doxepin

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.

Aufarbeitung

  1. customThe product was isolated by means of HPLC and evaporation of solvents

Quellen und Nachweise

ORD-Eintrag
ord-c0db4a8bd81f4d39b30e5697fbdc8eec
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09107898B2

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