HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Dimethylaminoacetophenone → (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Dimethylaminoacetophenone | HCID 75037 | — |
| Katalysator | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Lösungsmittel | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Produkt | (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one | HCID 71285027 | 35,8% |
Reaktionsschritte
A solution of 1-[4-(dimethylamino)phenyl]ethanone (500 mg, 3.1 mmol) in DMF-DMA (10 mL), toluene (10 mL), and AcOH (2 drops), was heated under reflux conditions for 48 h. The solution was concentrated and purified by flash column chromatography (hexanes:EtOAc=8:2˜1:1) to give the title compound (121 mg, 18%) as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09107916B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-902f43f21db94618b0be5351002cdefa |
| Quellennotiz | uspto-grants-2015_08 |