Hydrochloric Acid → 1-(2,2-Dihydroxymethyl-3-fluoropropyl)-2-nitroimidazole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

56.3 mg (0.206 mmol equivalents) of 2,2-dimethyl-5-fluoromethyl-5-[(2-nitro-1H-imidazol-1-yl)methyl]-1,3-dioxane was dissolved in 2 mL of methanol, 2 mL of 1 mol/L hydrochloric acid was added thereto, and the mixture was heated at 80° C. for 2 hours. After completion of the reaction, the reaction liquid was cooled to room temperature (25° C.), the solvent was then removed by distillation, and the obtained crude product was washed with ethyl acetate to give 47.3 mg (0.203 mmol equivalents) of 1-(2,2-dihydroxymethyl-3-fluoropropyl)-2-nitroimidazole (FIG. 2, Step 2).

Herkunft & Nachweise