Hydrochloric Acid → HCID 178513824, Verbindung
Reaktionsgleichung
O.O.Cl.[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11].Cl.C([O-])=O.[Na+]>>[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11]Komponenten
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
Under the nitrogen atmosphere, 1.5 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate prepared according to the method of Reference Example 2 was added to 18 mL of 0.45 mol/L hydrochloric acid and dissolved therein by heating to 50° C. At 50° C., 6 mL aqueous solution containing 1.9 g of sodium formate was added dropwise thereto. pH of the reaction mixture was 3.1. The reaction mixture was cooled to room temperature. The crystal was collected by filtration and then washed with a mixture liquid containing 1.5 mL of acetone and 3.0 mL of water followed by 4.5 mL of acetone to give 0.90 g of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate as a pale yellow crystal. The infrared absorption spectrum (ATR method) corresponded to that of Example 4.
Aufarbeitung
- dissolutiondissolved
- additionwas added dropwise
- temperatureThe reaction mixture was cooled to room temperature
- filtrationThe crystal was collected by filtration
- washwashed with a mixture liquid
- additioncontaining 1.5 mL of acetone and 3.0 mL of water
Quellen und Nachweise
- ORD-Eintrag
- ord-6520e88a78d94870b28c2dbc05390912
- Quelldatensatz
- uspto-grants-2015_08
- Patentnummer
- US09108928B2
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