(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate → (E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

HRID 514868Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 514868
[OH:1][C:2]1(/[CH:15]=[CH:16]/[CH2:17][C:18]([F:21])([F:20])[F:19])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.O1CCOCC1>[F:21][C:18]([F:19])([F:20])[CH2:17]/[CH:16]=[CH:15]/[C:2]1([OH:1])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Komponenten

3

Edukt 1

HCID 90447581(E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate

Produkt 1

HCID 90447571(E)-4-(4,4,4-trifluorobut-1-enyl)piperidin-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

A solution of (E)-tert-butyl 4-hydroxy-4-(4,4,4-trifluorobut-1-enyl)piperidine-1-carboxylate (200 mg, 0.65 mmol) in 3M HCl/1,4-dioxane (5 mL) was stirred at room temperature for 2 hours. The solution was evaporated to dryness under reduced pressure to give the product which was used in the next step without further purification. LC-MS: m/z 210.2 (M+H)+.

Aufarbeitung

  1. customThe solution was evaporated to dryness under reduced pressure
  2. customto give the product which
  3. customwas used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-33ba42fdad64425a9ae9196f52730cc5
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108921B2

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