Potassium Carbonate → HCID 86670925, Verbindung

HRID 515263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 515263
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([OH:34])([C:30]([F:33])([F:32])[F:31])[C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[F:27][C:26]([F:28])([F:29])[C:25]([C:22]1[CH:23]=[CH:24][C:19]([CH2:18][N:12]2[CH2:11][CH2:10][CH:9]([O:8][C:7]3[CH:15]=[CH:16][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)=[CH:20][CH:21]=1)([OH:34])[C:30]([F:31])([F:33])[F:32]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 219186534-(4-Nitrophenoxy)piperidineHCID 235273962-[4-(Bromomethyl)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol

Produkt 1

HCID 86670925HCID 86670925, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

4-(4-Nitrophenoxy)piperidine (2.70 mmol, 600 mg), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.70 mmol, 910 mg) and potassium carbonate (5.40 mmol, 746 mg) were combined and stirred at 70° C. in acetonitrile (20 mL) overnight. The reaction mixture was filtered and the filtrate concentrated under vacuum to afford the title compound. MS (ESI) m/z 490.0 [M+H]+

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ac89dcbe8e564db8a454abe2715aa522
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108939B2

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