Trifluoroacetic acid → 2-Fluoro-4-(piperidin-4-ylmethyl)aniline

HRID 515290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 515290
[NH2:1][C:2]1[CH:21]=[CH:20][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[F:22].FC(F)(F)C(O)=O>ClCCl>[F:22][C:3]1[CH:4]=[C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH:20]=[CH:21][C:2]=1[NH2:1]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67193052Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate

Produkt 1

HCID 671959362-Fluoro-4-(piperidin-4-ylmethyl)anilineAusbeute 118,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Tert-butyl 4-(4-amino-3-fluorobenzyl)piperidine-1-carboxylate (6.49 mmol, 2 g) was dissolved in dichloromethane (5 mL). Trifluoroacetic acid (3 mL) was added and the reaction mixture stirred at room temperature for 30 minutes. The reaction mixture was purified by SCX chromatography to give the intermediate 2-fluoro-4-(piperidin-4-ylmethyl)aniline (1.6 g) as a colourless oil.

Aufarbeitung

  1. customThe reaction mixture was purified by SCX chromatography

Quellen und Nachweise

ORD-Eintrag
ord-76db2c94a0b54794bb75234748a516d8
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108939B2

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