Cyclopropanemethanamine → Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoate

HRID 515324Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 515324
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[N:6]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)=[C:7]=[O:8]>ClCCl>[CH:1]1([CH2:4][NH:5][C:7](=[O:8])[NH:6][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 75646CyclopropanemethanamineHCID 589805Ethyl 4-isocyanatobenzoate

Produkt 1

HCID 3830959Ethyl 4-(3-(cyclopropylmethyl)ureido)benzoateAusbeute 107,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To cyclopropylmethanamine (57.5 mmol, 4.99 mL, 4.09 g) in dichloromethane (40 mL) was added to ethyl 4-isocyanatobenzoate (52.3 mmol, 10 g) in dichloromethane (45 mL) and the reaction stirred overnight. The reaction was then concentrated under reduced pressure to give the title compound (14.7 g).

Aufarbeitung

  1. concentrationThe reaction was then concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8687af6912874e2b8c73f7b33c2aea4b
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108939B2

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