HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Reserpine → 2-(3-Fluoro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Reserpine | HCID 5770 | — |
| Edukt | 4-Bromo-2-fluoro-1-phenoxybenzene | HCID 22736316 | — |
| Edukt | 2-Phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzonitrile | HCID 22736340 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 2-(3-Fluoro-4-phenoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 22736295 | — |
Reaktionsschritte
The title compound was prepared in a 65% from 4-bromo-2-fluoro-1-phenoxybenzene in a similar manner to that described for the preparation 2-phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 7.49(dd, 2H), 7.41(m, 2H), 7.18 (t, 1H), 7.08(d, 1H), 7.05(d, 2H), 1.30(s, 12H); RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, I mmin) tr 14.63 min.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06713474B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-24c64e3d2f1545e7ad1538b1d7a47b59 |
| Quellennotiz | uspto-grants-2004_03 |