1-Propanol → 3-Propoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

HRID 5159

Reaktionsgleichung

Reaktionsgleichung von HRID 5159
[CH3:1][C:2]([O:4][CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.B(F)(F)F.[CH2:23](O)CC>C(N(CC)CC)C>[CH2:2]([O:4][CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[CH:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])[CH2:1][CH3:23]

Komponenten

5

Edukt 3

HCID 10311-PropanolHCID 6356Boron trifluorideHCID 4413287-Aminocephalosporanic acid

Produkt 1

HCID 1317167883-Propoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

Using the procedure of Step A of Example 8, 27.2 g of 7-amino-cephalosporanic acid, 170 ml of the etherate of of boron trifluoride, 131 ml of propanol and 128 ml of triethylamine were reacted to obtain 17.4 g of raw product which was purified with hot hydrochloric acid and ammonium hydroxide to obtain 7.45 g of 3-propoxymethyl-7-amino-ceph-3-eme-4-carboxylic acid.

Aufarbeitung

  1. customwere reacted
  2. customto obtain 17.4 g of raw product which
  3. customwas purified with hot hydrochloric acid and ammonium hydroxide

Quellen und Nachweise

ORD-Eintrag
ord-332c42f9e23541eaa37b1a643ef16125
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05243043

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