C1(SC2C=CC=CC=2)C=CC=CC=1.[O:14]1[C:18]2([CH2:23][CH2:22][C:21](=[CH:24][C:25]([O:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[O:26])[CH2:20][CH2:19]2)[O:17][CH2:16][CH2:15]1.[H][H]>CO.[Pd].[C]>[O:14]1[C:18]2([CH2:23][CH2:22][CH:21]([CH2:24][C:25]([O:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:26])[CH2:20][CH2:19]2)[O:17][CH2:16][CH2:15]1Diphenyl sulfide (33 mg, 0.18 mmol) and 10% Pd-carbon (1.08 g) were added to a solution of benzyl 2-(1,4-dioxaspiro[4,5]decan-8-ylidene)acetate (5.0 g, 17.34 mmol) in methanol (50 ml) under a nitrogen gas stream, the atmosphere in the system was replaced five times with nitrogen gas, was then filled with hydrogen gas, followed by stirring under a hydrogen gas stream for 5 hr. The catalyst was removed by filtration through Celite pad and was washed with ethanol, and the filtrate was concentrated under reduced pressure to give the title compound as a yellow oil (4.1 g, yield 82%).
Wird geladen…
