Triethylamine → N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

HRID 51704

Reaktionsgleichung

Reaktionsgleichung von HRID 51704
[CH3:1][C:2]([CH3:7])=[CH:3][C:4](Cl)=[O:5].[Br:8][C:9]1[CH:16]=[CH:15][C:12]([NH:13][CH3:14])=[CH:11][CH:10]=1.C(N(CC)CC)C>ClCCl>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([N:13]([CH3:14])[C:4](=[O:5])[CH:3]=[C:2]([CH3:7])[CH3:1])=[CH:11][CH:10]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 2757052Benzenamine, 4-bromo-N-methyl-

Produkt 1

HCID 22568913N-(4-Bromophenyl)-N-methyl-3-methyl-2-butenamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3,3-Dimethylacryloyl chloride (3 mL, 27 mmol) was added to a solution of 4-bromo-N-methyl-aniline (4.55 g, 25 mmol) in 150 mL of dichloromethane followed after 5 minutes by triethyl amine (5 mL, 33 mmol). After 2.5 h at ambient temperature, the reaction mixture was washed with water and the organic phase was dried over anhydrous sodium sulfate and evaporated in vacuo to afford the title product as a brown oil in quantitative yield.

Aufarbeitung

  1. washthe reaction mixture was washed with water
  2. dry with materialthe organic phase was dried over anhydrous sodium sulfate
  3. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1edc07ddeab5417f92355e1390ad4d0a
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713647B2

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