Methanol → L-cysteic acid methyl ester hydrochloride

HRID 517340

Reaktionsgleichung

Reaktionsgleichung von HRID 517340
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

Produkt 1

HCID 86673321L-cysteic acid methyl ester hydrochlorideAusbeute 75 %

Versuchsvorschrift

L-cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

Quellen und Nachweise

ORD-Eintrag
ord-b64c9b6861254997bd7f20929fefe32b
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115107B2

Verknüpfte Notizen

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