4-Bromophenyl isocyanate → 4-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide

HRID 517417Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 517417
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>C(Cl)Cl>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:22])[NH:1][C:2]2[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 756094-Bromophenyl isocyanateHCID 2355274-Amino-N,N-dimethylbenzamide

Produkt 1

HCID 689172644-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamideAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-amino-N,N-dimethyl-benzamide (3.5 g, 0.0213 mol), TEA (2.15 g, 0.0213 mol) in DCM (50 mL) was added 4-bromophenyl isocyanate (5.07 g, 0.0256 mol). The reaction mixture was stirred at room temperature for 12 h. The white solid was obtained and was filtered and dried to afford the title compound [6.8 g, 88%]; LC-MS (ESI): Calculated mass: 361.0; Observed mass: 362.0 [M+H]+ (RT: 0.17 min).

Aufarbeitung

  1. customThe white solid was obtained
  2. filtrationwas filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-051ee5daeb974aa1b4af6dc36c889d69
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115092B2

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