2-Bromoethanol → 2-(4-Bromo-2-(trifluoromethyl)phenoxy)-ethanol

HRID 518000Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 518000
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH2:21][OH:22]>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:20][CH2:21][OH:22])=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

Komponenten

5

Edukt 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 142784o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro-

Produkt 1

HCID 576575832-(4-Bromo-2-(trifluoromethyl)phenoxy)-ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

4-Bromo-2-(trifluoromethyl)phenol (83 mmol, 20 g), potassium carbonate (166 mmol, 22.94 g) and 2-bromoethanol (124 mmol, 8.79 mL, 15.56 g) were combined and heated to reflux for overnight in Acetonitrile (200 mL). The reaction mixture was washed with water, 0.5M NaOH, dried over sodium sulfate and concentrated in vacuo. The resulting residue was taken up in hot heptane (300 mL) and allowed to crystallise. The solid was filtered off to afford 2-(4-bromo-2-(trifluoromethyl)-phenoxy)ethanol. (20.74 g)

Aufarbeitung

  1. temperatureheated
  2. washThe reaction mixture was washed with water, 0.5M NaOH
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customto crystallise
  6. filtrationThe solid was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-5de1fadde5dc471da8087ce9ea939a0e
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115126B2

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