HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5'-Bromo-2'-hydroxyacetophenone → 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| Edukt | 1-Phenyl-4-piperidinone | HCID 413009 | — |
| Edukt | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Produkt | 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one | HCID 66932220 | — |
Reaktionsschritte
1′-Phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for preparation of Intermediate 1, Step A, using 1-phenyl-piperidin-4-one (607 mg, 3.47 mmol) and 2-hydroxy-5-bromoacetophenone (746 mg, 3.47 mmol), giving 650 mg as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09115148B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-c0950ea8371547d0926ea53da7c061be |
| Quellennotiz | uspto-grants-2015_08 |