Methyl Acrylate → (E)-3-{1'-Phenyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

HRID 518174

Reaktionsgleichung

Reaktionsgleichung von HRID 518174
[C:1]1([N:7]2[CH2:12][CH2:11][C:10]3([CH2:21][C:20](=[O:22])[C:19]4[C:14](=[CH:15][CH:16]=[C:17](Br)[CH:18]=4)[O:13]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:24]([O:28][CH3:29])(=[O:27])[CH:25]=[CH2:26].COC(=O)/C=C/C1C=C2C(=CC=1)OC1(CCN(C(OC(C)(C)C)=O)CC1)CC2=O>>[CH3:29][O:28][C:24](=[O:27])/[CH:25]=[CH:26]/[C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[O:13][C:10]1([CH2:11][CH2:12][N:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:8][CH2:9]1)[CH2:21][C:20]2=[O:22]

Komponenten

4

Edukt 3

HCID 7294Methyl AcrylateHCID 52952087(E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl esterHCID 669322201'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one

Produkt 1

HCID 66932530(E)-3-{1'-Phenyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Versuchsvorschrift

(E)-3-{1′-Phenyl-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester was synthesized starting from 1′-phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one (650 mg, 1.75 mmol) and methyl acrylate (541 mg, 6.2 mmol) according to the procedure described for Intermediate 1, Step B, giving 541 mg of the product.

Quellen und Nachweise

ORD-Eintrag
ord-d9db2f394610439f95759c5cb041fcb5
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115148B2

Verknüpfte Notizen

Wird geladen…