HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyl Bromide → N-[7-(Benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-methyl-isonicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 2-methylpyridine-4-carboxylic Acid Hydrochloride | HCID 2762824 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 4-methoxy-N7-methyl-benzothiazole-2,7-diamine | HCID 22736978 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | N-[7-(Benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-methyl-isonicotinamide | HCID 10151026 | — |
Reaktionsschritte
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and benzyl bromide in DMF, then treatment with 2-methyl-isonicotinic acid hydrochloride, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 419 (M+H+, 100).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06713499B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-ee19fed81d054f7e9638c543dd0a1caa |
| Quellennotiz | uspto-grants-2004_03 |