HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzyl Bromide → N-[7-(Benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-bromo-isonicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzyl Bromide | HCID 7498 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 2-Bromoisonicotinic acid | HCID 222701 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | 4-methoxy-N7-methyl-benzothiazole-2,7-diamine | HCID 22736978 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | N-[7-(Benzyl-methyl-amino)-4-methoxy-benzothiazol-2-yl]-2-bromo-isonicotinamide | HCID 10238921 | — |
Reaktionsschritte
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and benzyl bromide in DMF, then treatment with 2-bromo-isonicotinic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 485 (M{81Br}+H+, 98), 483 (M{79Br}+H+, 100).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06713499B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-766d40b0b1ba4d8f86b8993316cf8687 |
| Quellennotiz | uspto-grants-2004_03 |