N-bromobutanimide → 9-Bromobenzimidazo[2,1-a]isoquinoline

HRID 519420Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 519420
C1C(=O)N([Br:8])C(=O)C1.[CH:9]1[C:18]2[C:17]3=[N:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[N:16]3[CH:15]=[CH:14][C:13]=2[CH:12]=[CH:11][CH:10]=1>C1COCC1>[Br:8][C:23]1[CH:24]=[CH:25][C:20]2[N:19]=[C:17]3[C:18]4[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=4[CH:14]=[CH:15][N:16]3[C:21]=2[CH:22]=1

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 612818Benzimidazo(2,1-a)isoquinoline

Produkt 1

HCID 710778419-Bromobenzimidazo[2,1-a]isoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

32.6 g (183 mmol) of NBS are added to a solution of 40 g (183 mmol) of benzimidazo[2,1-a]isoquinoline in 500 ml of THF, and the mixture is stirred at 60° C. for 4 h. The solution is subsequently stirred at room temperature overnight, the solid is filtered off with suction, washed with ethanol and dried. Yield: 51.3 g (181 mmol), 98%.

Aufarbeitung

  1. stirringThe solution is subsequently stirred at room temperature overnight
  2. filtrationthe solid is filtered off with suction
  3. washwashed with ethanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-5233474b9efa47b1b1f59595aa28299a
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09118022B2

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