HCID 610084, Verbindung → Methyl 3-phenyl-1-adamantaneacetate

HRID 51983

Reaktionsgleichung

Reaktionsgleichung von HRID 51983
Br[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]3)[CH2:3]1)[CH2:9]2.[Cl-].[Cl-].[Cl-].[Al+3]>C1C=CC=CC=1>[C:2]1([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([O:15][CH3:16])=[O:14])([CH2:5]4)[CH2:3]2)[CH2:9]3)[CH:11]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 610084HCID 610084, VerbindungHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 53665692Methyl 3-phenyl-1-adamantaneacetateAusbeute 202 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Methyl 3-bromoadamantaneacetate (80 g) (Aldrich Chemical Co. Milwaukee Wis.) was dissolved in benzene (1.6 L) under nitrogen. Aluminum trichloride (37.12 g) was added portionwise over 75 min. at ambient temperature. The reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L). The layers were separated and the organic layer was dried over sodium sulfate, filtered, and evaporated in vacuo to give methyl 3-phenyl-1-adamantaneacetate (80 g).

Aufarbeitung

  1. customThe reaction mixture was then quenched by the addition of 0.5M phosphoric acid (1.6 L)
  2. customThe layers were separated
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-33797f736a214462ba6cf92a008f2560
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616505

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