Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate → HCID 19962783, Verbindung

HRID 52017Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 52017
[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([O:31]CC3C=CC=CC=3)=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[C].[Pd]>[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([OH:31])=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 19962759Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

Produkt 1

HCID 19962783HCID 19962783, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

Aufarbeitung

  1. filtrationInsoluble matters were filtered off
  2. concentrationfiltrate was concentrated under reduced pressure
  3. customThe residue thereby obtained
  4. washwas washed with isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-842237a3d11e4c5aa8d4605933cc7330
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616537

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