Reaktionsgleichung
[C:1]([C:4]1[CH:5]=[C:6]([NH2:13])[C:7](=[CH:11][CH:12]=1)[C:8](O)=[O:9])([OH:3])=[O:2].[CH:14]([NH2:16])=O>>[C:1]([C:4]1[CH:5]=[C:6]2[C:7]([C:8](=[O:9])[NH:16][CH:14]=[N:13]2)=[CH:11][CH:12]=1)([OH:3])=[O:2]Komponenten
3
Versuchsvorschrift
Using an analogous procedure to that described in the first paragraph of the portion of Example 1 which is concerned with the preparation of starting materials, 4-carboxyanthranilic acid (14.2 g) was reacted with formamide to give 7-carboxyquinazolin-4-one (8.5 g). A mixture of a portion (4 g) of the material so obtained, methanol (40 ml) and concentrated sulphuric acid (2 ml) was stirred and heated to reflux for 6 hours. The mixture was cooled to ambient temperature and the precipitate was isolated. There was thus obtained 7-methoxycarbonylquinazolin-4-one (5.7 g).
Quellen und Nachweise
- ORD-Eintrag
- ord-3208fb59c51b4997946aafbfe8545c04
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05616582
Verknüpfte Notizen
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