Hydrochloric Acid → 4-bromo-2-chloro-1H-indole

HRID 520599Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 520599
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[N:6]2S(C1C=CC(C)=CC=1)(=O)=O.[OH-].[Na+].Cl>CC(O)C>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([Cl:21])[NH:6]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 682264944-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole

Produkt 1

HCID 197003094-bromo-2-chloro-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

4-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole (215 mg), IPA (2.5 ml) and 2 M NaOH (aq) (2.5 ml) were mixed in a microwave vial and heated in the microwave for 30 min at 120° C. The reaction was acidified using 2M HCl (aq) and then extracted with DCM, which was passed through a hydrophobic frit, then evaporated to dryness. The residue was triturated with methanol which was then evaporated to afford the title compound, 112 mg.

Aufarbeitung

  1. extractionextracted with DCM, which
  2. customevaporated to dryness
  3. customThe residue was triturated with methanol which
  4. customwas then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d646c431cbbf481e812a3bc780829b0b
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09326987B2

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