Pyrrole-2-Carboxylic Acid → N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]pyrrole-2-carboxamide

HRID 52060

Reaktionsgleichung

Reaktionsgleichung von HRID 52060
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25](O)=[O:26]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:25]([C:21]3[NH:20][CH:24]=[CH:23][CH:22]=3)=[O:26])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 12473Pyrrole-2-Carboxylic AcidHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Produkt 1

HCID 67726205N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]pyrrole-2-carboxamideAusbeute 80 %

Versuchsvorschrift

Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenylamine and 2-pyrrolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as colorless prisms, melting at 136°-137° C., in an 80% yield.

Quellen und Nachweise

ORD-Eintrag
ord-7b341d7581304abd9c60dcc448f0d626
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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