1,2,3-Thiadiazole-4-carboxylic acid → N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-1,2,3-thiadiazole-4-carboxamide

HRID 52070

Reaktionsgleichung

Reaktionsgleichung von HRID 52070
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[S:20]1[CH:24]=[C:23]([C:25](O)=[O:26])[N:22]=[N:21]1>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:25]([C:23]3[N:22]=[N:21][S:20][CH:24]=3)=[O:26])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 3514181,2,3-Thiadiazole-4-carboxylic acidHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Produkt 1

HCID 67725873N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-1,2,3-thiadiazole-4-carboxamideAusbeute 52 %

Versuchsvorschrift

Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenylamine and 1,2,3-thiadiazole-4-carboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as colorless needles, melting at 70°-72° C., in a 52% yield.

Quellen und Nachweise

ORD-Eintrag
ord-d7b348f07e5949bbad759742942e6b29
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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