Pyrazole-4-carboxylic acid → N-{4-[4-(1-Pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenyl}pyrazole-4-carboxamide

HRID 52071

Reaktionsgleichung

Reaktionsgleichung von HRID 52071
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14]/[CH:15]=[CH:16]\[CH2:17][NH2:18])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:19]1[CH:23]=[C:22]([C:24](O)=[O:25])[CH:21]=[N:20]1>>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14]/[CH:15]=[CH:16]\[CH2:17][NH:18][C:24]([C:22]3[CH:23]=[N:19][NH:20][CH:21]=3)=[O:25])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 3015937Pyrazole-4-carboxylic acidHCID 150531284-[4-(1-Pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenylamine

Produkt 1

HCID 67725971N-{4-[4-(1-Pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenyl}pyrazole-4-carboxamideAusbeute 34 %

Versuchsvorschrift

Following a procedure similar to that described in Example 13, but using 4-[4-(1-pyrrolidinylmethyl)-2-pyridyloxy]-cis-2-butenylamine and 4-pyrazolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 57°-61° C., in a 34% yield.

Quellen und Nachweise

ORD-Eintrag
ord-65cbfa9f3d2f43d8a0423c90930c102f
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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