N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-chloroacetamide → HCID 178521530, Verbindung

HRID 52082

Reaktionsgleichung

Reaktionsgleichung von HRID 52082
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:23])[CH2:21]Cl)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[SH:24][C:25]1[N:29]=[CH:28][NH:27][N:26]=1>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:23])[CH2:21][S:24][C:25]3[N:29]=[CH:28][NH:27][N:26]=3)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 67725626N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-chloroacetamideHCID 178527894HCID 178527894, Verbindung

Produkt 1

HCID 178521530HCID 178521530, VerbindungAusbeute 91 %

Versuchsvorschrift

Following a procedure similar to that described in Example 33, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-2-chloroacetamide (prepared as described in Preparation 1) and 3-mercapto-1,2,4-triazole as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 65°-67° C., in a 91% yield.

Quellen und Nachweise

ORD-Eintrag
ord-d6eb3ccc027f4a8ebbe76dcd095d4b01
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

Verknüpfte Notizen

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