1,4-Oxathian-2-one → N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-hydroxyethylthio)acetamide

HRID 52100

Reaktionsgleichung

Reaktionsgleichung von HRID 52100
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:21]1[CH2:26][CH2:25][S:24][CH2:23][C:22]1=[O:27]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:22](=[O:27])[CH2:23][S:24][CH2:25][CH2:26][OH:21])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 3510601,4-Oxathian-2-oneHCID 199629605-(4-Piperidinomethyl-2-pyridyloxy)pentylamine

Produkt 1

HCID 19962903N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-hydroxyethylthio)acetamideAusbeute 78 %

Versuchsvorschrift

Following a procedure similar to that described in Example 68, but using 5-(4-piperidinomethyl-2-pyridyloxy)pentylamine and 1,4-oxathian-2-one as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 78% yield.

Quellen und Nachweise

ORD-Eintrag
ord-8463a783272e498a913f45b8e4db18a2
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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