HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Oxo-1,3-dihydroindole-6-carboxylic acid → 6-(cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridine-1-carbonyl)-1,3-dihydro-indol-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Oxo-1,3-dihydroindole-6-carboxylic acid | HCID 7213323 | — |
| Edukt | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Edukt | cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine | HCID 58123900 | — |
| Produkt | 6-(cis-2,3,4,4a,9,9a-Hexahydro-indeno[2,1-b]pyridine-1-carbonyl)-1,3-dihydro-indol-2-one | HCID 67224171 | 34% |
Reaktionsschritte
The title compound is prepared from 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid and cis-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate is used]. Yield: 34% of theory; LC (method 4): tR=1.88 min; Mass spectrum (ESI+): m/z=333 [m+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09328072B2 |
| Quelldatensatz | uspto-grants-2016_05 |
| ORD ID | ord-a5d90208426e4dc9b2370fd62354929b |
| Quellennotiz | uspto-grants-2016_05 |