2-(3,5-Difluorophenyl)propan-2-ol → 2-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH:18]([OH:20])[CH3:19])[CH:5]=[C:6]([F:17])[C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1.F[C:22]1C=C(C(O)(C)C)C=C(F)C=1>>[F:17][C:6]1[CH:5]=[C:4]([C:18]([OH:20])([CH3:22])[CH3:19])[CH:3]=[C:2]([F:1])[C:7]=1[B:8]1[O:12][C:11]([CH3:13])([CH3:14])[C:10]([CH3:15])([CH3:16])[O:9]1Komponenten
3
Versuchsvorschrift
Following the procedure of Intermediate 106, replacing 1-(3,5-difluorophenyl)ethanol with 2-(3,5-difluorophenyl)propan-2-ol (see US2012/225062) provided the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-2d40828508a843f79da6c2e3b98e4bc9
- Quelldatensatz
- uspto-grants-2016_05