Potassium Cyanide → (1-Oxo-2,3-dihydro-1H-pyrrolizin-2-yl)acetonitrile
Reaktionsgleichung
CN([CH2:4][CH:5]1[CH2:12][N:11]2[C:7](=[CH:8][CH:9]=[CH:10]2)[C:6]1=[O:13])C.[C-:14]#[N:15].[K+]>>[C:14]([CH2:4][CH:5]1[CH2:12][N:11]2[C:7](=[CH:8][CH:9]=[CH:10]2)[C:6]1=[O:13])#[N:15]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
To 100 ml H2O0 were added 8.6% of compound 2 and 5.2 g KCN. The solution was gently heated to 100° C. and kept stirring for 10 minutes. After cooling to r.t., the reaction mixture was extracted with CH2CI2 (60×3). Evaporated the solvent, 6 g oil was obtained. Purified by column chromatography on silica gel, 4 g of compound 8 was obtained as white powder, mp 68° C., yield 68%.
Aufarbeitung
- temperatureAfter cooling to r.t.
- extractionthe reaction mixture was extracted with CH2CI2 (60×3)
- customEvaporated the solvent
Quellen und Nachweise
- ORD-Eintrag
- ord-785f0cdf06ca404cbfc61e979beadff8
- Quelldatensatz
- uspto-grants-1997_04
- Patentnummer
- US05616604
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