Imipramine → CID 16052002

HRID 522498

Reaktionsgleichung

Reaktionsgleichung von HRID 522498
[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1.[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=2[CH2:44][CH2:43][C:42]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]1=2)[CH3:32]>C(OCC)(=O)C>[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=2[CH2:43][CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][C:46]1=2)[CH3:32].[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1

Komponenten

4

Edukt 2

HCID 3696ImipramineHCID 8546Pamoic Acid

Produkt 1

HCID 16052002CID 16052002Ausbeute 136,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a slurry of Pamoic acid (32.4 g) in ethyl acetate (250 mL) in a clean round bottomed flask, Imipramine (85 g, pre-generated from Imipramine hydrochloride −90 g, sodium hydroxide −18 kg in water, 60-100 mL) solution in ethyl acetate is added maintaining the temperature below 50° C. for 3-4 h. After complete addition, the reaction mixture is stirred at room temperature for about 12-14 h. The bright yellow slurry thus obtained is filtered and washed with ethyl acetate (400 mL) and dried to get Imipramine Pamoate (76 g, 96%) as bright yellow crystalline product.

Aufarbeitung

  1. temperaturemaintaining the temperature below 50° C. for 3-4 h
  2. additionAfter complete addition
  3. customThe bright yellow slurry thus obtained
  4. filtrationis filtered
  5. washwashed with ethyl acetate (400 mL)
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4e116daca564458e839b5e6478c057df
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09334240B2

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