Imipramine → CID 16052002

HRID 522499

Reaktionsgleichung

Reaktionsgleichung von HRID 522499
[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1.[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][C:45]=2[CH2:44][CH2:43][C:42]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]1=2)[CH3:32]>C(OCC)(=O)C>[CH3:30][N:31]([CH2:33][CH2:34][CH2:35][N:36]1[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][C:42]=2[CH2:43][CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][C:46]1=2)[CH3:32].[CH:1]1[CH:2]=[CH:3][C:4]2[C:5](=[CH:7][C:8]([C:27]([OH:29])=[O:28])=[C:9]([OH:26])[C:10]=2[CH2:11][C:12]2[C:21]([OH:22])=[C:20]([C:23]([OH:25])=[O:24])[CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][CH:16]=[CH:17]3)[CH:6]=1

Komponenten

4

Edukt 2

HCID 3696ImipramineHCID 8546Pamoic Acid

Produkt 1

HCID 16052002CID 16052002Ausbeute 130,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a slurry of Pamoic acid (32.4 g) in ethyl acetate (500 mL) in a clean round bottomed flask, Imipramine (150 g) solution in ethyl acetate is added at such a rate that the temperature remains below 50° C. for 3-4 h. After complete addition, the reaction mixture is stirred at room temperature for about 12-14 h. The bright yellow slurry thus obtained is filtered and washed with ethyl acetate (200 mL) and dried to get Imipramine Pamoate (73 g, 92%) as bright yellow crystalline product.

Aufarbeitung

  1. additionAfter complete addition
  2. customThe bright yellow slurry thus obtained
  3. filtrationis filtered
  4. washwashed with ethyl acetate (200 mL)
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4a65c4596e164399a2862199fd4b3204
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09334240B2

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